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Session 5: Gene Regulation and Cell Circuitry

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When:
1:30 PM, Monday 12 Jun 2023 (2 hours)
Where:
Loyola campus - Concordia University - SP building - room S110 (basement level S1)

Sub Sessions

1:30 PM - 2:00 PM | 30 minutes

Precise editing of human hematopoietic stem and progenitor cells (HSPC) is of interest both for the treatment of genetic disorders and for disease modeling. The advent of CRISPR/Cas has made such editing possible, however, current strategies have remained limited to 10-20% efficiency. Uses requiring purity thus need to include selection markers. This also limits donor selection to adeno-associated virus (AAV), as single stranded oligonucleotide donors (ssODNs) are not long enough to incorp...

2:00 PM - 2:30 PM | 30 minutes

Genome-reduced cells have a lower number of genes that makes them especially interesting for systems and synthetic biology. Yet, genome reduction entails intense genomic modifications that often result in growth defects or other undesirable phenotypes. Using a suite of tools including adaptive evolution, metabolic modeling, and machine learning, we were able to diagnose and fix a constitutive oxidative stress response occurring in Escherichia coli DGF-298. This strain derives from E. coli ...

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