Sunday 11 June, 2023
Utilizing synthetic biology to advance therapeutics. Synthetic biology has transformed how cells can be reprogrammed, providing a means to reliably and predictably control cell behavior with the assembly of genetic parts into more complex synthetic gene circuits. Using these approaches, we are programming bacteria and stem cells with novel genetic tools to control genes and pathways that result in changes in their native function for desired outcomes. Our work ...
- Etienne Laurent - MISO Chip - Microfluidic Systems for Next-Generation Functional Cancer Diagnostics
- Noémie-Manuelle Dorval Courchesne - Fabrication of textile-protein materials for responsible wearables
- Nicholas Gold - A biofoundry for microbial cell factories and mammalian cell lines: accelerating discovery and development
- 2 Oral presentations selected from abstracts
Sign-up for a workshop here! Workshop 1 - Alexandre Rochette - NEB - Golden Gate Workshop for graduate students only - max 20 participantsWhile ...
4:00pm - 5:00pm Posters P1-P23- Automation for Synthetic Biology- Systems Biology meets Synthetic Biology- Gene Regulation and Cell Circuitry 5:00pm - 6:00pm Posters P24-P53- Genome Engineering and Therapeutics- Metabolic Engineering and Bioprocessing Circuitry
Monday 12 June, 2023
- Anna Jezierski - Advancing induced pluripotent stem cell derived chimeric antigen receptor based natural killer cell therapy leveraging genome engineering approaches to advance off-the-shelf therapies
- Alejandro Álvarez Quilón - CRISPR and Base Editing Genetic Screens Enable the Discovery and Validation of Drug Targets for Precision Oncology
- Thierry Bertomeu - Large scale genome-wide CRISPR/Cas9 chemogenomic KO screens reveal drug mechanisms of action and identify novel gene functions
- 4 Oral presentations selected from abstracts
Engineered proteins, mRNA constructs and genes are constructed via gene assembly or mutagenesis and cloned into a vector for expression and or scale up. Groups may either construct their sequence of interest from shorter chemically synthesized oligos, or order fragments from third-party gene synthesis companies who use chemically synthesized oligos as a starting point. Both approaches create a bottleneck in which each day ...
Deciphering genome regulation or: How I learned to stop worrying and love random DNA. Gene expression is regulated by transcription factors that work together to read cis-regulatory DNA sequences. A primary aim of my group is to decipher the “cis-regulatory code” - the rules that cells use to determine when, where, and how much genes should be expressed. While cis-regulation has proven to be exceedingly complex, recent advances in our ability to query the activ...
