Session 4: Systems Biology meets Synthetic Biology
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The mechanisms of action of most antifungal drugs are well known. However, we still do not know many of the resistance mechanisms. Still to be discovered are the set of potential resistance mutations, the conditions that affect their likelihood of occurrence, and the fitness benefits and tradeoff they incur. I will present our most recent attempts to fill these knowledge gaps using budding yeast as a model and one of the oldest antifungals, flucytosine. We performed experiments at two leve...
The basal breast cancer subtype is enriched for triple negative breast cancer (TNBC) and displays consistent large chromosomal deletions. Here, we characterize the evolution and maintenance of chromosome 4p (chr4p) loss in basal breast cancer. TCGA data analysis showed recurrent deletion of chr4p in basal breast cancer. Phylogenetic analysis of a unique panel of 23 primary tumor/patient derived xenograft basal breast canc...
