Engineered proteins, mRNA constructs and genes are constructed via gene assembly or mutagenesis and cloned into a vector for expression and or scale up. Groups may either construct their sequence of interest from shorter chemically synthesized oligos, or order fragments from third-party gene synthesis companies who use chemically synthesized oligos as a starting point.  Both approaches create a bottleneck in which each day of delay is costly in terms of time to final product.

DNA Script developed an automated oligo synthesis benchtop platform, powered by enzymatic DNA synthesis, that can produce oligos for gene assembly in a matter of hours within the confines of your lab. Researchers can synthesize a plate of oligonucleotides overnight and assemble 1-2 KB genes in as little as 3 days.

With more control over the supply of DNA oligos and development costs, foundries and protein engineering labs can ensure consistent productivity and accelerate the iterative design-build-test cycles that are keystones in a high-throughput engineering lab.