Sex differences in cerebrovascular reactivity and cerebral blood flow across the lifespan
MRI acquisitions were completed as part of larger studies wherein 62 females participated.
A T1 sequence was acquired as was a pseudo-continuous arterial spin labelling sequence at
rest and during a hypercapnia manipulation. Resting CBF and CVR maps were estimated
after preprocessing and registered to MNI space. Regression analyses, accounting for age
and education, revealed a significant negative relationship between age and CBF, as well as
Our results confirm cerebrovascular health declines in females during the healthy aging process, for both CBF and CVR. This is likely due to changes in vascular stiffness during aging . The role of sex hormones in mediating these changes should be ascertained in future cross-sectional and longitudinal studies. Finally, similar studies should investigate the effects of aging and hormones in males to obtain a comprehensive picture of healthy cerebrovascular aging across the population.