Background: Cellular senescence, cell growth cycle arrest, is a marker of cellular aging. Obesity is considered a disease of accelerated aging as it shares several co-morbidities with aging, such as type 2 diabetes mellitus (T2DM). Objective: To determine regional differences in markers of cellular senescence and how these compare in obese individuals with and without T2DM. Methods: Pre-menopausal females undergoing bariatric surgery were categorized as obese-metabolically healthy...

Background: During atherosclerotic plaque development, vascular smooth muscle cells (VSMC) undergo dedifferentiation, resulting in a synthetic, less contractile progenitor state. This transition is marked by changes in mitochondrial respiration and increased reactive oxygen species (ROS) production. These changes in bioenergetics play a critical role in atherogenesis via facilitation of VSMC migration towards the intima. Objective: The objective of this study was to evaluate t...

According to the oxidative stress theory, reactive species are key drivers of inflammation and cardiovascular disease (1). The electron transport chain of the mitochondria accounts for ≈90 of the intracellular radioactive oxygen species (2). Interestingly, while low-carbohydrate high-protein diets promote weight loss, animal experiments show that they could also lead to mitochondrial dysfunction and therefore, oxidative stress and inflammation (3). In parallel, research in the last decade has...

Background: Different exercise intensity has a various effect on the immune system. Lactate is one of the factors that releases in exercise, on one hand, higher lactate concentration not also apoptosis of peripheral blood mononuclear cells (PBMCs) decrease but also the survival of the PBMCs increase (Elsaser et al., 2017), on the other hand...