This talk will discuss sleep of children as they transition to teens in the context of research that examines associations between brain systems that regulate sleep/wake behavior—the circadian timing system and the sleep homeostatic system. For example, adolescents’ circadian timing becomes later; their sleep “need” does not diminish; their sleep homeostatic system is also modified in a way that can modify sleep timing. A major implication of this work has been in the area of education, sp...

Circadian clock genes are widely expressed in mammalian brain. Despite considerable knowledge about the role of these genes in the generation of circadian rhythms in the suprachiasmatic nucleus, the master circadian clock, insight into brain-region specific function of these genes limited. Studies in our laboratory investigate the role of core clock gene, Bmal1 and Per2 in the control of behaviors governed by the striatum, a forebrain structure critical in in motor control, reward processi...

Sleep and circadian disturbances are common and represent risk factors for the development of some of the most prevalent and challenging chronic illnesses, such as cardio-metabolic and neurodegenerative disorders.Circadian rhythms are ubiquitous in all organisms. These rhythms, maintained through a complex molecular transcription-translation feedback loop are present throughout the brain and body, and play a key role in the regulation of nearly all physiological and behavioral processes. S...