Evidence consistently demonstrates that aging is associated with declines to cerebrovascular health. Sex distinctions have been identified as well, where studies have shown that cerebral blood flow (CBF) declines linearly across the lifespan in both sexes, yet females have greater CBF compared to males [1]. Cerebrovascular reactivity (CVR) has also been identified as a marker of cerebrovascular health and is shown to decline with age [1,2], but the potential sex differences are currently uncl...

Circadian clock genes are widely expressed in mammalian brain. Despite considerable knowledge about the role of these genes in the generation of circadian rhythms in the suprachiasmatic nucleus, the master circadian clock, insight into brain-region specific function of these genes limited. Studies in our laboratory investigate the role of core clock gene, Bmal1 and Per2 in the control of behaviors governed by the striatum, a forebrain structure critical in in motor control, reward processi...